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GLP-1 medications slow gastric emptying, making people feel full for longer and eat far less than they used to

GLP-1 acts locally in the GI tract and via the vagus nerve, a key autonomic pathway that, when activated, further slows stomach emptying

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However, there may be exceptional circumstances where dose escalation is delayed, such as: Significant gastrointestinal side effects that have not resolved after one month Concurrent acute illness or hospitalisation Patient preference to extend the titration period under medical supervision Concerns about tolerability in frail or elderly patients Healthcare professionals should review patients after starting Rybelsus to assess tolerability, reinforce dosing instructions, and plan dose escalation