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Last month (May 2025), Novo announced that the US Food and Drug Administration (FDA) accepted its new drug application (NDA) submission for an investigational once-daily oral formulation of Wegovy (semaglutide) for chronic weight management in adults living with obesity or overweight with one or more comorbid conditions and to reduce the risk of major adverse cardiovascular events in adults with overweight or obesity and established cardiovascular disease
If you use exogenous insulin, its like 1iu, maybe 2, for maximum benefit
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Beyond weight loss, GLP-1 agents reduce circulating insulin levels, attenuate insulin-like growth factor signaling, and lower systemic inflammatory markers
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