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Injection technique for tirzepatide autoinjector pens (Mounjaro/Zepbound) follows specific steps outlined in the manufacturer's Instructions for Use: Remove the pen cap and verify the medication appears clear and colorless to slightly yellow Select and clean an appropriate injection site (abdomen, thigh, or back of upper arm) Place the clear base flat against the skin at the injection site Unlock the pen by turning the lock ring Press and hold the gray injection button

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As with headache, distinguishing treatment-related fatigue from background symptoms in obese populations with potential sleep disorders presents methodological challenges

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