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After reaching the intestine (pH 6-7), the capsule shell gradually dissolves and releases the active ingredient

J Biol Chem 259:90829089 Nagy-Szakal D, Barupal DK, Lee B, Che X, Williams BL, Kahn EJR, Ukaigwe JE, Bateman L, Klimas NG, Komaroff AL, Levine S, Montoya JG, Peterson DL, Levin B, Hornig M, Fiehn O, Lipkin WI (2018) Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics

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In some cases, increased vitamin C can result in kidney stones or even hemodialysis in people who are G6PD-deficient (a disease in which some drugs cause red blood cells to break down)

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