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There are several benefits of vitamin C, one of which is its role in collagen production

Uricase-deficient rats with similarly stable serum uric acid to humans are sensitive model animals for studying hyperuricemia

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In addition, the high expression of NRF2 enhances the expression of downstream SOD1, an important antioxidant enzyme that plays a crucial role in protecting cells from oxidative damage [36]

noted reduced expression of the GHR in the kidneys of 5/6 nephrectomized animals, which was associated with elevated pro-inflammatory cytokines, suggesting that GH-insensitivity in uremia is a general phenomenon and not restricted to the liver and growth plates ( vide supra ) [174]