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J Intern Med 265(2):174192

R., Mokhtar, S

This also disrupted the pro-fibrotic pathways of TGF/Smad and Wnt/-catenin, altering pro-fibrotic protein levels in kidney cells treated with TGF and lessening renal fibrosis caused by one-sided ureteral blockage, suggesting SINs ability to suppress oxidative stress and safeguard the kidneys (110)

NA generated by gut microbes is also able to maintain a local NAD + /NAM pool that can be a source of circulating NA even in the absence of dietary precursor administration 126,127