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Inhibition of glutamine uptake or catabolism shifts activated HSCs to a more quiescent state, thereby alleviating fibrosis

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Based on this, an investigator-initiated, phase III, double-blind, randomized controlled trial was performed to evaluate the efficacy and safety of high-dose selenium (2000 g/day) intravenously in a 1:1 ratio for the prevention of CIPN in 68 platinum-sensitive cancer patients treated with paclitaxel, carboplatin, and bevacizumab [110]

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2011 Nov;38(11):1761-6