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Activity-balanced GLP-1/GDF15 dual agonist reduces body weight and metabolic disorder in mice and non-human primates

Current antidiabetic medications aim at decreasing glucose levels, either by improving insulin secretion in the remaining -cells (using insulin secretagogues), by improving the response to insulin in target tissues (using insulin sensitizers), or by replacing the missing insulin (using exogenous insulin treatment)

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Incretin effect is sufficient for glucose control in developing rats