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160,161,162,163,164,165 Both adults and children have been found to exhibit genetic mutations that affect baseline renal urate excretion levels
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Fourth, residual confounding remains a fundamental limitation, as crucial variables including socioeconomic status, educational attainment, baseline cognitive reserve, lifestyle factors, and genetic risk are often inadequately captured or adjusted for in claims-based databases
Long term administration of agonists could potentially lead to unanticipated consequences in these organs
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