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Oxidative stress and hypertension
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HES (for 10 days) to CIPN rats significantly reduced PTX-induced increases in MDA, NF-B, IL-1, TNF-, COX-2, nNOS, JAK2, STAT3, and GFAP levels with neuropathic pain and alleviated endoplasmic reticulum stress (ERS) [133]
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Researchers often study it in lab work on Nicotinamide N-Methyltransferase (NNMT)
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