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Physiology of Incretins GLP-1 and GIP are incretin hormones secreted from the intestine in response to food intake and stimulate glucose-dependent insulin release, -cell proliferation, and cellular survival

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The production of free radicals also increases during illness, which can result in complications

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[8] [9] Additionally, GLP-1 suppresses glucagon secretion from pancreatic alpha cells, which helps prevent excessive glucose production by the liver

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Several GLP-1 analogs, including orally available semaglutide, are clinically approved and are used to treat type 2 diabetes

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