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VDAC, a multi-functional mitochondrial protein regulating cell life and death

Label status: In January 2025, the Ozempic label was updated to state that it is not recommended in patients with severe gastroparesis, but does not indicate that the drug itself may cause the condition

In the STEP UP clinical trial, the 7.2-mg dose demonstrated a mean weight loss of 20.7% at 72 weeks, compared with a reduction of 17.5% with the previously approved semaglutide (Wegovy) injection (2.4 mg) and 2.4% with placebo

Ju B-G, Solum D, Song EJ et al (2004) Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway

To help prevent muscle loss, experts recommend strength-training exercises, adequate protein intake, and proper hydration throughout treatment