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GLP-1 RA Addition to Background Sulfonylurea Therapy Similar to the discussion above about background insulin, it is prudent in many cases to hold or reduce the dose of background sulfonylurea therapy (an initial 50% dose reduction is reasonable in many patients) when starting a GLP-1 RA

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52.5% of those receiving placebo ( n =31) and 52.0% receiving semaglutide ( n =26) also reported TEAEs (Table 3)

Individuals without severe gastrointestinal disease , active pancreatitis, or other contraindications relevant to incretin-based therapies

Cholesterol-Lowering Drugs 4