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Assessing heat tolerance through productive vs physiological indicators
The cytokine level measured through the ELISA technique reflected auspicious outcomes in terms of reduction in IL-1, IL-6, and TNF- levels
GCL is specific for the glutamyl moiety and is regulated physiologically by: (a) non-allosteric feedback competitive inhibition by GSH (Ki=2.3mM), which involves binding of GSH to the glutamate and another site on the enzyme [8, 9] and (b) availability of its precursor, cysteine [1] .The apparent Km values of GCL for glutamate is 1.8 mM, and for cysteine and 0.10.3 mM [9]
At the same time, SFN administration resulted in decreased abundance of potentially harmful bacteria like Corynebacterium and Staphylococcus
Mechanistic information has been published on how glutathione deactivates mutagens through the activity of various glutathione dependent enzymes such as glutathione S-transferase [2] and glutathione peroxidase [3]
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