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These ligands include the endogenous substrate Tf and several different antibodies and peptides that bind to different epitopes of the receptor with Tf as the most extensively studied ligand for TfR-directed brain targeting [20]
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By modulating the expression of growth factors and antioxidant enzymes, the peptide accelerates tissue repair processes
This paradigm shift argues that the most effective therapies will be those that can disrupt this intercellular vicious cycle, either through multi-targeted agents like L-F001 or combination regimens (Peng, 2022)
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