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Although greater weight reduction was observed in patients receiving tirzepatide, these results reflect associations rather than causal effects and may be influenced by confounding by indication, differences in baseline characteristics, treatment selection, dose escalation, and tolerability in routine clinical practice

In the skin, collagen provides structure, elasticity, and hydration, which are essential for maintaining a youthful appearance

Lower doses used during the titration phase (typically 0.25 mg to 0.5 mg weekly) often cost less than maintenance doses of 1 mg or 2.4 mg

If guided self-help is declined, ineffective, or unavailable, NICE recommends offering a specifically adapted form of cognitive behavioural therapy (CBT-ED), typically delivered over 1620 sessions