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Bioavailability is the measure of how much of a substance actually enters your circulation and is able to have an effect

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Obviously, the activation mechanism of P-Dex exerts a very important effect on its pharmacodynamic characteristics

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Clinical studies have also indicated that metformin alone can increase GLP-1 levels, via a mechanism distinct from DPP-4 inhibition, and that combination therapy has a complementary effect on GLP-1 concentrations [27]