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ROS cause oxidative damage to various cellular components and disrupt the balance between ECM catabolism and anabolism 119
A considerable number of these deaths are attributable to modifiable risk factors, particularly diet and lifestyle, with dietary practices alone implicated in roughly half of these cases (295)
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In other words, in addition to inhibiting the expression of p-STAT3, GHK-Cu likely targets other pathways that inhibit the expression of inflammatory factors
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