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LTF can also be synthesized by pro-inflammatory activated microglia (Fillebeen et al., 2001), and may also be related to the iron disturbances in the AD brain with senescent iron-accumulating microglia and lipid-rich microglia (Zeineh et al., 2015
Whereas CD5 and IL-2 influence immune system functions and MMP2 is important in maintaining the extracellular matrix in skin, tendons and other connective tissue, and Tram1 increases protein production
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