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GEP44 activates insulin-independent glucose uptake in muscle tissue via its interactions with Y1-R Despite the positive ISR data and hypothesis that GEP12 would prove superior to GEP44, we noted in in vivo studies (vide infra) that it was considerably inferior to GEP44 in terms of food intake and body weight reduction

Lipid nanoparticles (LNPs) have the ability to encompass both hydrophilic and lipophilic compounds, emerging as encouraging drug delivery systems for improved active targeting and penetration into the BBB (164)

AT-7687, a novel GIPR peptide antagonist, combined with a GLP-1 agonist, leads to enhanced weight loss and metabolic improvements in cynomolgus monkeys

Patel et al., 2019)

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