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GLP-1s are incretin-based agents that amplify glucose-stimulated insulin secretion, suppress inappropriate glucagon release, slow gastric emptying, and promote satiety

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Immunohistochemical staining for Nrf2, NQO1, and HO-1 expression on knee joint histological sections demonstrated that metformin administration significantly increased the numbers of Nrf2, NQO1, and HO-1-positive chondrocytes compared to those in OA group (Fig