Its clinical use is currently limited to a single product, known as pramlintide, which is approved as an adjunct therapy in persons with insulin-treated diabetes
--- Safety and Interaction Profile NAD+ precursors are among the safest longevity supplements available
Other benefits include ease of manufacturing and thus lower cost than peptides
The first one is, as we think about the monotherapy versus combination therapy options, I guess one way to interpret it is that different peripheral compartments may contribute differently to efficacy
Haigis KM, Kendall KR, Wang Y, Cheung A, Haigis MC, Glickman JN, Niwa-Kawakita M, Sweet-Cordero A, Sebolt-Leopold J, Shannon KM, Settleman J, Giovannini M, Jacks T (2008) Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon