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Tirzepatide is a different, newer molecule that hits two receptors instead of one (GLP-1 and GIP), sold as Mounjaro for diabetes and Zepbound for weight management

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They include being on the starter dose of 2.5 mg, needing a higher dose, other underlying medical reasons or hormonal imbalances, not eating in a calorie deficit, not getting enough protein and dietary fiber, or not working out