Cross-trial comparisons suggest retatrutide produces greater mean weight loss than semaglutide, though tolerability profiles are broadly similar
In contrast to the incidence of cutaneous melanoma, the incidence of oral melanoma has remained stable for more than 25 years
This typically includes thyroid function tests (TSH, free T4), fasting glucose and hemoglobin A1c, lipid panel, and potentially cortisol levels if Cushing's syndrome is suspected
The evidence from the Cochrane review (Showell et al
Seek urgent assessment via NHS 111, eye casualty/A&E, or your GP if you experience: Sudden vision loss or significant deterioration in either eye Floaters (new dark spots or strings drifting through your vision), especially if numerous or increasing Flashes of light in your peripheral vision A curtain or shadow moving across your visual field Distorted vision where straight lines appear wavy or bent Difficulty reading or recognising faces that develops rapidly Blurred vision that doesn't improve with blinking or resting your eyes Eye pain with vision changes or a red, painful eye These symptoms may indicate complications such as vitreous haemorrhage (bleeding into the gel-filled centre of the eye), retinal detachment , or diabetic macular oedema (swelling of the central retina)