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I-BET151 (a selective inhibitor of BET) can reduce joint inflammation and bone loss by blocking MMP-1, MMP-3, IL-6, and IL-8 production in RA FLS (190, 306)
Chem Res Toxicol
Disadvantages involve higher long-term costs from continuous product consumption, possible adaptation reducing treatment responsiveness over time, psychological dependency on continuous application, and unknown very long-term effects from years of daily copper supplementation
The order of treatments and measurements was also randomized
Immunohistochemical staining showed higher expression of p16 in keloids than that in normal skin ( p = 0.01
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