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For context, the toxic dose is estimated at roughly 22,500 mg, compared to a typical weekly dose of about 6 mg

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The ML210 small molecule is likely to exert its inhibitory effect by covalently modifying the selenocysteine of GPX4 [162, 163]

Although we cannot rule out a contribution of glycolysis to this ATP increase and did not directly assess the activity of other complexes, we observed increased 5FU sensitivity with inhibitors of ETC complexes IIV, genetic ablation of CI and CIV, and sensitizer genes from CRISPR screening covering additional complexes (CIII and CV)