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The expression of GCL is highly sensitive to environmental threats and is upregulated by the Nrf2 transcription factor when the cell detects oxidative stress
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Llabani E, Hicklin RW, Lee HY, Motika SE, Crawford LA, Weerapana E, et al
PubMed Central, doi:10.1007/s10815-008-9246-x
Due to its potential function in the occurrence and development of breast cancer, GPx2 is suggested as a potential target for the prevention and treatment of breast cancer
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