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How Wegovy Affects Your Lipid Panel: Cholesterol, Triglycerides, and LDL Changes on Semaglutide 2.4 mg At a glance Drug / Wegovy (semaglutide 2.4 mg), a once-weekly GLP-1 receptor agonist Triglycerides / Reduced by approximately 12% to 18% across STEP trials LDL cholesterol / Decreased by roughly 3% to 4% from baseline Total cholesterol / Lowered by approximately 2% to 4% versus placebo HDL cholesterol / Increased modestly by 1% to 3% in most trial arms VLDL cholesterol / Decreased in proportion to triglyceride reductions Timeline / Lipid improvements measurable by week 16, sustained through week 68 Mechanism / Both direct GLP-1 receptor effects on hepatic lipid metabolism and indirect weight-loss-mediated improvements Monitoring / Baseline lipid panel recommended before starting, repeat at 3 to 6 months SELECT trial / Semaglutide 2.4 mg reduced major adverse cardiovascular events by 20% in patients with established cardiovascular disease What Happens to Your Lipid Panel on Wegovy Wegovy shifts nearly every marker on a standard lipid panel in a favorable direction

Bartolomaeus, H

Long-term nutritional outcomes are still being studied, especially beyond extended use

This is also seen in rodents

This blog post will break down the key themes discussed in the episode, providing detailed, actionable advice and expert recommendations