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The study found that hypoxia-induced upregulation of ECHS1 interacts with PGK1, leading to a decrease in PGK1 crotonylation levels
To achieve equivalent plasma concentrations, oral doses would need to be 35 times higher than injection doses approximately 150250mg methionine daily which increases gastrointestinal side effects like nausea and diarrhea
The most commonly reported are gastrointestinal symptoms like nausea, vomiting and diarrhoea
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