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The short-term IP dosing triggered DNA repair and inflammatory TNF-alpha/NF-kB pathways in females, which are canonical responses to metabolic stress or tissue injury

"Increased levels of oxidative stress markers and proinflammatory cytokines in migraine patients." Cellular and Molecular Biology , 62(1), 1-5

The data suggest that among the three major fatty acid metabolizing pathways in the arachidonic acid cascade (COX, LOX and CYP), oxylipins derived from the COX and CYP pathways are the most altered metabolites and showed ibuprofen-mediated sex-specific differences in male and female mice liver

Nonprotein thiols and disulfides in rat epididymal spermatozoa and epididymal fluid: Role of gamma-glutamyl-transpeptidase in sperm maturation

2 Mucolytic NAC has been used for its mucolytic (mucus-thinning) properties for decades