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Neither compound is FDA-approved for human use

However, at higher than physiologic pH levels, the stimulation of hexokinase and phosphofructokinase activity merely results in the accumulation of fructose diphosphate and triosephosphates, because the availability of nicotinamide adenine dinucleotide (NAD) + for the glyceraldehyde phosphate dehydrogenase (GAPDH) reaction becomes a limiting factor

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This action subsequently influences the metabolic process that needs NAD+