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doi: Talenezhad, N., Mohammadi, M., Ramezani-Jolfaie, N., Mozaffari-Khosravi, H
The biological significance of MT-1 as a research compound rests on its selectivity profile within the melanocortin receptor family , while native -MSH activates MC1R, MC3R, MC4R, and MC5R with overlapping potency, MT-1s structural modifications confer preferential activity at MC1R relative to the centrally expressed MC3R and MC4R subtypes, making it a more MC1R-selective research tool than either the native peptide or Melanotan II
All procedures were carried out under Institutional Animal Care and Use Committee approval and in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals
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