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Subcutaneous injection provides near 100% bioavailability and systemic distribution, whereas topical application is limited by skin barrier penetration

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Symptoms can improve before zonulin normalizes, so it catches incomplete healing

There is no cure for vitiligo, but it can be treated to reduce the appearance of the symptoms

Tony emphasizes the significance of this shift from a sales perspective, noting that while brands always want to make stronger claims, Kyowa maintains a conservative approach as a Japanese company (Kyowa Hakko is a part of Kyowa Kirin Co., Ltd )