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doi:10.3109/00365529609009147 34 HuntJEHolstJJJeppesenPBKissowH

The mechanisms by which certain medications bring about oral mucosal melanin hyperpigmentation include upregulation of tyrosinase activity, deposition of complexes of the drug with pre-existing melanin in the mucosa, or induction of local inflammatory reactions with the triggering of melanin production [11, 38]

It does not cause a euphoric feeling once patients become tolerant to its effects

Afamelanotide for prevention of phototoxicity in erythropoietic protoporphyria

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