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Restrictions on patients with a history of cancer or bariatric surgery, as well as on those taking concomitant medications have further hampered enrollment

Certainty for body weight and BMI was rated as low, downgraded for risk of bias and imprecision, but not for inconsistency, as both included RCTs demonstrated consistent direction and magnitude of effect favoring GLP-1 receptor agonists

[11] [12] These studies show that patients who continue GLP-1 therapy maintain significantly more weight loss compared to those who discontinue treatment, with most patients regaining weight after stopping medication