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Pharmacokinetic modeling and clinical experience support this approach, though no head-to-head randomized trial has compared 1.5 mg twice weekly versus 2.5 mg once weekly

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Nec-1 functions through the specifically targeting of Receptor-Interacting Protein Kinase 1 (RIPK1), inducing disruption in the assembly of the necrosome, consequently impeding the execution of necroptotic cell death