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elegans , MDPs like MOAG-4 (orthologous to human MOTS-c) extend lifespan by over 20% via AMPK-dependent metabolic reprogramming 42 , while the 28-aa peptide ALP-1 (encoded by an sORF in the alh-6 gene) suppresses protein aggregation in aged neurons 43

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This depletion may contribute to airway inflammation, mucus buildup, and the kind of bronchospasm that sends people reaching for their inhaler

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