Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)
Injections deliver the peptide to systemic circulation more reliably
Unlike exogenous GH, sermorelin does not bypass the hypothalamic-pituitary axis, so side effects such as carpal tunnel syndrome, insulin resistance, edema, and joint pain are rare
Always consult a licensed healthcare provider before starting any new vitamin, supplement or injection program
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