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Soffer DE, Marston NA, Maki KC, et al

doi: 10.3389/fcell.2021.630248 Received 17 November 2020 Accepted 16 February 2021 Published 18 March 2021 Volume 9 - 2021 Edited by Martin Van Der Laan, Saarland University, Germany Reviewed by Eirini Lionaki, Foundation for Research and Technology Hellas (FORTH), Greece

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In this study, histopathological examination of both right sides in two groups was of great value not only in confirming the type of melasma but also adding another objective tool in evaluation of treatment response in two groups, it demonstrated a decrease in melanin in basal cell layer in epidermal types and in melanin and melanophages in dermis in mixed types in H and E and MF stained sections after treatment compared with baseline

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