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Intestinal microorganisms metabolize TML into trimethyl-5-aminovaleric acid (TMAVA), which can competitively inhibit the binding of -BB to BBD, thereby inhibiting carnitine biosynthesis and FAO in the liver, promoting steatosis and aggravating fatty liver [250]
Enzyme samples were incubated with phosphate buffer, which included the appropriate concentrations of glutathione (GSH) and peroxide as substrates, to determine Gpx activity
Carnitine therapy for the treatment of metabolic syndrome and cardiovascular disease: evidence and controversies
Most supporting evidence comes from animal research
Within this rapidly evolving field, the lysosome has emerged as a central intracellular target for cancer nanomedicine
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