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The MHRA advises periodic monitoring of B12 levels in at-risk or symptomatic patients taking metformin

Explored as a possible aid for recovery and lean-mass preservation in frail or catabolic populations, though a Merck-sponsored Phase 2b trial in elderly hip-fracture patients (Adunsky et al., 2011, Archives of Gerontology and Geriatrics, PMID 21067829) was halted early over a cardiac safety signal rather than demonstrating a clear functional benefit

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Allergic reactions are uncommon, but if you were to experience symptoms like swelling of the tongue or throat, hives, or difficulty breathing after an injection, that could indicate an allergy and you should seek medical help immediately