One small crossover trial found that morning semaglutide injections before 8am produced roughly 15% lower post-prandial glucose compared to evening doses after 8pm
One study explored mechanistic associations between GLP-1 functioning and mood disorders in humans: a post-mortem investigation showed that, compared with healthy controls, patients who had been diagnosed with mood disorders had lower expression of the gene encoding for GLP-1R in the dorso-lateral prefrontal cortex and the hippocampus, whereas this association was not observed in the brain tissue of people with schizophrenia 176
Klysz D, Tai X, Robert PA, Craveiro M, Cretenet G, Oburoglu L, et al
Storage guidance in this article is therefore directed at personnel working within authorised investigational contexts such as clinical trial sites operating under the Medicines for Human Use (Clinical Trials) Regulations 2004 and not at individuals seeking to self-administer the compound
Phentermine-topiramate (Qsymia) is the strongest fully oral, currently available weight loss medication at 8-10% average weight loss