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(Middle) Upon reaching the tumor site, these nanocarriers exert their therapeutic effects through three primary mechanisms (1): Macrophage Reprogramming, where the delivery of immunomodulators (e.g., TLR agonists) converts tumor-promoting, anti-inflammatory M2 macrophages into tumor-suppressive, pro-inflammatory M1 macrophages
The K7M2 cells were maintained in DMEM, also supplemented with 10% FBS and 1% P/S
The exact mechanisms of pMPM1 suppression by RSL3 remains to be uncovered
10.1183/09031936.94.07030431 81 MouthuyP
Therapeutic agents like finerenone can effectively modulate the PANoptotic cascade to alleviate local immune infiltration and tubular damage (213)
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