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People who are already relatively lean (under 25% body fat for men or under 32% for women) may find that GLP-1 medications produce less dramatic weight loss but still improve body composition through targeted fat reduction
Bhattacharya R, et al
As of 2024, there are small studies to suggest that topical or oral formulations of glutathione can help reduce melasma severity
To this regard, GSH may also have direct anti-SARS-CoV-2 potential: indeed a computational study indicates that the binding of spike protein to ACE2 is maximal when ACE2-sulfur groups are in the form of disulfides and impaired when fully reduced to thiols: hence a prooxidant environment with low levels of GSH would favor viruses cellular entry (Hati and Bhattacharyya, 2020)
Epidemiological data confirms this overlap
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