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El-Achkar, A., et al
Approval: 2021 SEMGLEE (insulin glargine-yfgn) is biosimilar* to LANTUS (insulin glargine)
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[1] [2] While some studies have examined surrogate markers such as HOMA-IR (Homeostatic Model Assessment for Insulin Resistance), improvements in insulin resistance with semaglutide are primarily indirect and mediated through weight loss and improved glycaemic control
Healthcare providers should consider assessing kidney function before initiating therapy in at-risk patients and monitor kidney function when severe gastrointestinal adverse reactions occur, particularly in those with pre-existing renal impairment
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