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Similarly, in breast cancer, LOH at this locus occurred in approximately 36% of breast cancer tissues, and GPx1 with a leucine-containing allele exhibited lower GPx1 activities in response to stimulation than GPx1 a proline-containing allele [88]
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143 ThomsonR.Carrera-PachecoS.GillamE
Furthermore, NPD389 binding to ME2 in fast-binding mode impairs its activity, 188 and embonic acid (EA) induces the cellular senescence of H1299 cancer cells through its noncompetitive inhibitory activity against ME2
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