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Pregnant or lactating women and people with other medical conditions should consult a doctor before using

The bottom of subpocket C in proximity to the chimera ligand contained several mostly non-polar (purple) probes with positive free energy values, indicating that it may be filled with additional non-polar substituents

A direct effect of tirzepatide at the GIPR in adipose tissue surrounding and within the kidney, such as perirenal fat and intrarenal fat, may favorably affect inflammation known to contribute to kidney dysfunction

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10.1038/clpt.2011.336 Clin