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Abbreviations BBB: Bloodbrain barrier CFS: Chronic fatigue syndrome CNS: Central nervous system CoA: Coenzyme A COVID-19: Coronavirus disease 2019 CrAT: Carnitine acetyltransferase CRP: C-reactive protein HPA: Hypothalamicpituitaryadrenal IDO: Indoleamine 2,3-dioxygenase IL-2: Interleukin-2 IMD: Immunometabolic depression MDD: Major depressive disorder ME: Myalgic encephalomyelitis mGluR2: Metabotropic glutamate receptor 2 MS: Multiple sclerosis NMDA: N -Methyl-d-aspartate NMR: Nuclear magnetic resonance Nrf2: Nuclear factor erythroid 2-related factor 2 OCTN2: Organic cation novel type 2 transporter OCT1: Organic cation transporter 1 PAIS: Post-acute infection syndromes PASC: Post-acute sequelae of SARS-CoV-2 infection PDC: Pyruvate dehydrogenase complex PGD2S: Prostaglandin D2 synthase gene QUIN: Quinolinic acid ROS: Reactive oxygen species Trp: Tryptophan TCA: Tricarboxylic acid HO-1: Heme oxygenase 1 PUFAs: Polyunsaturated fatty acids CACT: Carnitine-acylcarnitine translocase MRI: Magnetic resonance imaging [ 18 F]FDG-PET/CT: [ 18 F]Fluorodeoxyglucose positron emission tomography/computed tomography References Abraham NG, Kappas A (2008) Pharmacological and clinical aspects of heme oxygenase
When mitochondrial function becomes impaired, ROS production may increase while energy production becomes less efficient
N.et al (2001)
Journal of Pakistan Association of Dermatologists, juillet-septembre 2016, publication en ligne 6
Higher natural growth hormone levels support: Increased lipolysis, the process your body uses to break down stored fat for energy Preservation of lean muscle mass during a caloric deficit Deeper, more restorative sleep, which directly affects metabolic hormones Better recovery from exercise, allowing more consistent training sessions Improved insulin sensitivity over time Ipamorelin does not work like a stimulant or an appetite suppressant
