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The older versions of these drugs were initially approved for the treatment of diabetes

Garg SK et al

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A biodistribution study revealed that the accumulation of DOX in tumors was over twice as high in the DOX/LAAM GSH-CQD group compared to any other organs, whereas free DOX was mainly distributed in the liver, and the fluorescence intensity of the tumor was only half that of the liver at this time point (Fig

These data were used to create two groups of mice ( n = 8 per group) with similar average body weights and whole-body metabolic profiles