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Before starting GLP-1 therapy, consult with your healthcare provider to determine if it is appropriate for you

Importantly, the VECAD IGF- 1R KD model recapitulates key features of early microvascular aging prior to the onset of overt muscle atrophy, making it a useful experimental system for studying pre-sarcopenia and identifying early vascular biomarkers of functional decline

Profile 3: Poorly Controlled or Unstable Psychiatric Illness Semaglutide and tirzepatide carry no specific psychiatric black box warning, but the FDA's Adverse Event Reporting System (FAERS) contains post-marketing reports of suicidal ideation associated with GLP-1 agents, prompting the FDA to open a signal evaluation in 2023 [7]

JAMA: the journal of the American Medical Association 302, 412 (2009)